ABSTRACT
Objectives: The purpose of the study was to place cadaverdermal allograft in patients with burn and non-healing ulcerwounds and observe their biologic response.1. To identify clinical success rate of take of cadavericdermal allograft2. To evaluate infection / rejection rate of cadaveric dermalallograft3. To confirm take of allograft by histological features andneovascularization after applying cadaveric dermalallograft.Method: This study was done on 50 patients suffering fromburn and nonhealing ulcer wounds. Patients of all age groupsand both sexes were taken. Dermal allografts were harvestedfrom cadaver after taking consent from relatives. These graftswere applied to wound sites after treating it with glycerol andcryopreservation and their biological responses wereassessed.Results: In this study, on follow up for 2 months, out of 50patients, the graft was survived in 41 (82%) patients andrejected in 9 (18%) patients. Out of 41 patients, the graft wasdetached and wounds were completely healed in 33(66%)patients and graft was still intact in 8(16%) patients. Graft takeup success was assessed by histopathologically showingneovascularization.Conclusion: It was observed that epidermis depleted allografthas proved to be an effective material for wound coverage dueto absence of langerhans cells. Further cryopreservationincreased its viability and reduced immune reaction. Glycerolacted as an effective virucidal agent.